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http://ac.els-cdn.com/S092012111100...t=1389746978_ff07e0c7cc4cae3f88a405a065033f60
Abstract
Summary Multiple forms of the ketogenic diet (KD) have been successfully used to treat
drug-resistant epilepsy, however its mainstream use as a first-line therapy is still limited. Further
investigation into its clinical efficacy as well as the molecular basis of activity is likely to
assist in the reversal of any resistance to its implementation. In this review we shall attempt
to elucidate the current state of experimental and clinical data concerning the neuroprotective
and cognitive effects of the KD in both humans and animals. Generally, it has been shown
by many research groups that effective implementation of KD exerts strong neuroprotective
effects with respect to social behavior and cognition. We will also elucidate the role of KD
in the interesting relationship between sleep, epilepsy and memory. Currently available evidence
also indicates that, under appropriate control, and with further studies investigating any
potential long-term side effects, the KD is also a relatively safe intervention, especially when
compared to traditional anti-epileptic pharmacotherapeutics. In addition, due to its neuroprotective
capacity, the KD may also hold potential benefit for the treatment of other neurological
or neurodegenerative disorders.
© 2011 Elsevier B.V. All rights reserved.
Andere potentiële bronnen
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